Q: I just purchased an iPod shuffle and would like to know if it’s safe to use it on a computer that I am already using to sync my iPod 40 GB.
A: Of course! iTunes can handle multiple iPods, as long as only one is set to synchronize automatically.
But the iPod shuffle is a special case, since iTunes works a bit differently with this model. When you plug the iPod shuffle into your computer, you’ll see the difference; an Autofill option will pop up, and you can even keep the shuffle’s music library listing on-screen when it’s unplugged, so that you can prepare a new song list for your next synchronization.
The iPod shuffle’s manual explains how to work with its unique capabilities.