Apple does not recommend running disk utilities like Norton Speed Disk, Disk Scan and Disk Defragmenter. It’s not really needed as the drive is not written to and erased nearly as much as a typical hard drive. If you’re emphatic about cleaning up your drive it’s best just to do a full Restore with the Apple Software Updater. This reformats the drive (defragmenting it in the process) and has the added benefit of creating a new clean iPod database which over extended periods of use can get corrupted.
I'm a passionate, long-time lover of Apple products, and was a civil draftsman and graphic designer before creating the iLounge web site. My prior projects include work for The Los Angeles Times' LATimes.com, and the company Creative Domain, where I developed websites for clients including Columbia Pictures, Disney, Fox Studios, Universal Pictures and Warner Brothers. As the Publisher of iLounge, I direct the site's community forums, photo galleries, iPod User Group, and general business affairs, which have grown under my watch to over sixteen million page views every month. I'm happily married with one daughter, one dog (Rocket the Wonderdog), one cat (Ferris), many iPods, iPhones, iPads, and two turntables.