According to a report from CNN Money, the upcoming Palm Pre will sync with iTunes out of the box with no third-party software required. The Palm Pre appears to iTunes in the same way that an iPod or iPhone would, except that FairPlay-protected content cannot be transferred to the device.
Although very early versions of iTunes for Mac provided direct support for other MP3 players, and third-party programs have long been available to allow various non-Apple MP3 players to sync with iTunes, this is the first example of an apparently unauthorized, non-Apple device actually providing its own direct iTunes integration. Not surprisingly, many of the Palm Pre engineering and development team are former Apple employees, including Jon Rubinstein, one of the designers of the original iPod.
The synchronization feature works with both PC and Mac versions of iTunes.